No matter where or in what format you submit, you should always read the submission guidelines for each publication where you're submitting your work. If a publication specifically calls down a certain type/genre of writing, then why submit work in that vein? Additionally, ensuring that your work is laid out in standard manuscript format will go a long way. Work that is properly formatted makes for ease of reading and commenting, and that makes for a happy editor.
First time submitters, take heart. There are plenty of helpful sites that are only a quick web search away!
Does anyone have general submission tips to share?
Follow the blog via RSS for updates on what's happening with Blue Spider Press.